PRKCZ — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ucn-01 (SCHEMBL259162)	1.00	12/20
Staurosporine (SCHEMBL8156)	1.00	10/20
Staurosporine (SCHEMBL8157)	1.00	10/20
Balanol (SCHEMBL62128)	1.00	9/20
Balanol (SCHEMBL62129)	1.00	9/20
SCHEMBL162443	0.61	8/20
SCHEMBL136381	0.61	7/20
SCHEMBL117745	0.56	7/20
Ammonia Solution, Strong (SCHEMBL250660)	0.47	7/20
SCHEMBL190590	1.00	6/20
SCHEMBL260178	0.81	6/20
SCHEMBL115053	0.56	6/20
SCHEMBL106734	0.53	6/20
Fasudil (SCHEMBL4674)	1.00	5/20
SCHEMBL123495	1.00	5/20
SCHEMBL123496	1.00	5/20
SCHEMBL190415	0.63	5/20
SCHEMBL78989	0.62	5/20
Phorbol (SCHEMBL72895)	0.62	5/20
SCHEMBL190414	0.62	5/20

Clinical trials — most relevant to PRKCZ by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma	PHASE2	RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers	PHASE1/PHASE2	NOT_YET_RECRUITING
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer	PHASE1	WITHDRAWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.	nan	NOT_YET_RECRUITING
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Fat Induced Insulin Resistance and Atherosclerosis	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure	nan	RECRUITING
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a PRKCZ binder may also engage these)

Protein	Name	Similarity
O19111	—	1.000	O19111 →
Q02956	—	1.000	Q02956 →
P09217	—	1.000	P09217 →
Q62074	—	1.000	Q62074 →
Q5R4K9	—	1.000	Q5R4K9 →
F1M7Y5	—	1.000	F1M7Y5 →
Q90XF2	—	1.000	Q90XF2 →
PRKCI	Protein kinase C iota type	1.000	landscape →
Q19266	—	1.000	Q19266 →
A8WUG4	—	1.000	A8WUG4 →
A1Z9X0	—	1.000	A1Z9X0 →
Q8BRK8	—	0.995	Q8BRK8 →
PHKG2	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0.995	landscape →
RPS6KB1	Ribosomal protein S6 kinase beta-1	0.994	landscape →
Q66I46	—	0.994	Q66I46 →
Q6TJY3	—	0.993	Q6TJY3 →
Q8BSK8	—	0.993	Q8BSK8 →
Q64682	—	0.993	Q64682 →
Q6PFQ0	—	0.993	Q6PFQ0 →
Q09639	—	0.993	Q09639 →
P51138	—	0.993	P51138 →
Q9JJX8	—	0.993	Q9JJX8 →
Q39030	—	0.993	Q39030 →
Q02111	—	0.993	Q02111 →
Q5RD00	—	0.993	Q5RD00 →
Q8VZD5	—	0.993	Q8VZD5 →
Q9DB30	—	0.993	Q9DB30 →
P54645	—	0.993	P54645 →
P07934	—	0.992	P07934 →
P51137	—	0.992	P51137 →