SCHEMBL10490647

SCHEMBL10490647

CCC[Si](CCC)(CCC)c1ccc([C]=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 2/20 0.47
NR1H3 Q13133 2/20 0.47
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20178548 0.85 NR1H2 (0.41) NR1H2NR1H3ESR1
SCHEMBL10490632 0.72 NR1H2 (0.44) NR1H2NR1H3ESR1
SCHEMBL25405388 0.71 NR1H2 (0.52) NR1H2NR1H3ESR1ESR2
SCHEMBL10490653 0.71 NR1H2 (0.47) NR1H2NR1H3
SCHEMBL3889886 0.70 NR1H2 (0.50) NR1H2NR1H3ESR1ESR2
SCHEMBL7630021 0.70 NR1H2 (0.37) NR1H2NR1H3
SCHEMBL29174513 0.70 NR1H2 (0.50) NR1H2NR1H3ESR1ESR2
SCHEMBL26592455 0.70 NR1H2 (0.60) NR1H2NR1H3
SCHEMBL28506522 0.68 NR1H2 (0.49) NR1H2NR1H3
SCHEMBL104811 0.68 APP (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US claimed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP claimed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US disclosed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP disclosed