Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 9/20 | 0.75 |
| ▸ | MEN1 | O00255 | 9/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.75 |
| ▸ | MAPT | P10636 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.75 |
| ▸ | RECQL | P46063 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | APEX1 | P27695 | 2/20 | 0.75 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.70 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 1/20 | 0.63 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.63 |
| ▸ | ALPL | P05186 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10492212 | 1.00 | POLB (0.75) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL13056337 | 1.00 | POLB (0.75) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3971529 | 0.88 | KMT2A (0.87) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3971531 | 0.88 | KMT2A (0.87) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8181657 | 0.87 | KDR (0.69) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8181654 | 0.87 | KDR (0.69) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3893459 | 0.86 | MAPT (1.00) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3893463 | 0.86 | MAPT (1.00) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3892662 | 0.84 | MAPT (0.92) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3892665 | 0.84 | MAPT (0.92) | POLBMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831045-A | Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |
| US-4791126-A | Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredients | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| EP-0047109-B1 | RHODANINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND ALDOSE REDUCTASE INHIBITOR CONTAINING THE RHODANINE DERIVATIVES AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 1985-01-02 | — | — | EP | disclosed |
| US-4464382-A | Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| EP-0047109-A1 | Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-03-10 | — | — | EP | disclosed |