Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 11/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATXN2 | Q99700 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105919 | 0.91 | ENPP2 (0.77) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL3050762 | 0.88 | ENPP2 (0.83) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL15135277 | 0.84 | ENPP2 (0.66) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL105676 | 0.84 | ENPP2 (0.62) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL7959501 | 0.82 | ENPP2 (0.74) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL106566 | 0.82 | ENPP2 (0.59) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL171674 | 0.80 | ENPP2 (1.00) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL172148 | 0.80 | ENPP2 (0.66) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL104294 | 0.80 | ENPP2 (0.65) | ENPP2KCNH2GRIN2BGRIN1GRIN2D | |
| SCHEMBL3056061 | 0.79 | ENPP2 (0.70) | ENPP2KCNH2GRIN2BGRIN1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | claimed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | claimed |
| EP-2193118-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES FOR TREATING TUMOURS | Merck Patent GmbH (DE) | 2010-06-09 | — | — | EP | claimed |
| WO-2009046841-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES FOR TREATING TUMOURS | MERCK PATENT GMBH (DE) | 2009-04-16 | — | — | WO | claimed |
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | disclosed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |