Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PTPRF | P10586 | 1/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692690 | 0.96 | MAPT (0.56) | MAPTGAAPTPRFPTPN2PTPN1 | |
| SCHEMBL9800415 | 0.87 | MEN1 (0.56) | MAPTGAAPTPRFPTPN2PTPN1 | |
| SCHEMBL1937924 | 0.85 | CYP19A1 (0.58) | MAPTGAACYP19A1CA2MEN1 | |
| SCHEMBL10494724 | 0.85 | MAPT (0.58) | MAPTGAAPTPRFPTPN2PTPN1 | |
| SCHEMBL6804800 | 0.85 | MAPT (0.58) | MAPTGAAPTPRFPTPN2PTPN1 | |
| SCHEMBL813026 | 0.83 | CA2 (0.68) | CA2CA1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL121841 | 0.83 | CYP19A1 (0.80) | MAPTCYP19A1CA2CA1MEN1 | |
| SCHEMBL3563645 | 0.82 | MAPT (0.60) | MAPTPTPRFPTPN2PTPN1PTPN11 | |
| SCHEMBL30963225 | 0.82 | HTT (0.66) | MAPTGAAPTPRFPTPN2PTPN1 | |
| SCHEMBL10494719 | 0.81 | CA2 (0.62) | MAPTGAAPTPRFPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816470-A | Heterocyclic compounds | GLAXO GROUP LIMITED | 1989-03-28 | — | — | US | disclosed |