Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | GBA1 | P04062 | 3/20 | 0.31 |
| ▸ | GALR3 | O60755 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL10495255 | 1.00 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495156 | 1.00 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495303 | 1.00 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495192 | 1.00 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495160 | 1.00 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495142 | 1.00 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495137 | 0.98 | DNM1 (0.39) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495171 | 0.95 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495161 | 0.95 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 | |
| Trimethylammonium SCHEMBL10495280 | 0.95 | DNM1 (0.42) | DNM1EPHX1TSHRTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4871874-A | Process for producing dienes | ETHYL CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |