Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA6 | P23280 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009277 | 0.80 | TTR (0.52) | CA1CA2CA4CA6TTR | |
| SCHEMBL124390 | 0.80 | TTR (0.52) | CA1CA2CA4CA6TTR | |
| SCHEMBL10495686 | 0.78 | CA1 (0.37) | CA1CA2CA4CA6TTR | |
| SCHEMBL31320039 | 0.77 | CA1 (0.43) | CA1CA2CA4CA6TTR | |
| SCHEMBL10964657 | 0.74 | ERN1 (0.43) | CA1CA2CA4CA6TTR | |
| SCHEMBL69904 | 0.72 | CA1 (0.67) | CA1CA2CA4CA6TTR | |
| SCHEMBL1003689 | 0.72 | TSHR (0.43) | CA1CA2GPR35TSHRCYP3A4 | |
| SCHEMBL10495740 | 0.71 | CSNK2A2 (0.34) | MAP2K1AKR1B1 | |
| SCHEMBL28017537 | 0.70 | CA1 (0.63) | CA1CA2CA4CA6TTR | |
| SCHEMBL4351080 | 0.70 | TTR (0.62) | TTRTSHRCYP3A4TDP1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4869913-A | DIETETICS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-09-26 | — | — | US | disclosed |
| US-4522839-A | 3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-06-11 | — | — | US | disclosed |
| EP-0055689-B1 | 3-SUBSTITUTED 2,4,6-TRIHALOGENOBENZAMIDES AND THEIR SALTS, THEIR PREPARATION AND THEIR USE AS SUBSTITUTES FOR NATURAL SWEETENING AGENTS, AND SWEETENERS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-07-04 | — | — | EP | disclosed |
| US-4429152-A | DIABETES, DIETETICS | SCHERING, AKTIENGESELLSCHAFT (DE) | 1984-01-31 | — | — | US | disclosed |
| EP-0055689-A1 | 3-Substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-07-07 | — | — | EP | disclosed |