Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Lixazinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 known ✓ | Q9H244 | 1/20 | 0.97 |
| ▸ | PDE3B | Q13370 | 20/20 | 0.97 |
| ▸ | PDE3A | Q14432 | 20/20 | 0.97 |
| ▸ | PDE4A | P27815 | 1/20 | 0.97 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.97 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lixazinone SCHEMBL29381710 | 0.99 | PDE3B (0.95) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10375017 | 0.98 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Lixazinone SCHEMBL7719533 | 0.98 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Lixazinone SCHEMBL29605513 | 0.98 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10374855 | 0.98 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Lixazinone SCHEMBL10375012 | 0.97 | PDE3B (0.98) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10375980 | 0.97 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10374566 | 0.96 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10375862 | 0.95 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10374986 | 0.95 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837239-A | IMIDAZO(2,1-B)QUINAZOLINYLOXYALKYLAMIDES | SYNTEX (U.S.A.) INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0212647-A2 | Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins | SYNTEX (U.S.A.) INC. (US) | 1987-03-04 | — | — | EP | disclosed |