Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 10/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23316883 | 0.65 | ALDH1A1 (0.47) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL8462330 | 0.65 | — | — | |
| SCHEMBL18966709 | 0.64 | CHRM5 (0.57) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL503332 | 0.62 | RECQL (0.34) | ALDH1A1HPGDHSD17B10ALOX12TDP1 | |
| SCHEMBL21402172 | 0.62 | — | — | |
| SCHEMBL9534606 | 0.61 | ALDH1A1 (0.46) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL5334097 | 0.61 | CHRM5 (0.44) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL30987970 | 0.61 | ALDH1A1 (0.55) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL10491245 | 0.61 | CHRM5 (0.44) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL7386543 | 0.61 | RECQL (0.33) | ALDH1A1HPGDHSD17B10ALOX12TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088903-B1 | 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTER DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-11-23 | — | — | EP | claimed |
| US-4841054-A | A LOW TOXICITY, HIGH STABILITY MEDICATION FOR HYPERTENSIVE ACTIVITY | INSTITUTE ORGANICHESKOGO SINTEZA AKADEMII NAUK LATVISISKOI SSR | 1989-06-20 | — | — | US | disclosed |