Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496326 | 0.80 | KDM4E (0.50) | KEAP1SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL235080 | 0.79 | KDM4E (0.65) | KEAP1SMN1; SMN2KDM4EALDH1A1GLA | |
| SCHEMBL10501575 | 0.77 | — | — | |
| SCHEMBL6077409 | 0.76 | KDM4E (0.46) | KEAP1SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL674062 | 0.76 | ALDH1A1 (0.52) | KEAP1SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6044315 | 0.76 | GLA (0.47) | KEAP1SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL18434868 | 0.76 | KDM4E (0.46) | KEAP1SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL20329460 | 0.76 | SMN1; SMN2 (0.46) | KEAP1SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL11856358 | 0.76 | KDM4E (0.70) | KEAP1SMN1; SMN2KDM4EALDH1A1GLA | |
| SCHEMBL10913328 | 0.76 | KDM4E (0.70) | KEAP1SMN1; SMN2KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0171217-B1 | FUSED-RING HETEROCYCLIC COMPOUNDS A PROCESS FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE | SANKYO COMPANY LIMITED (JP) | 1989-05-03 | — | — | EP | disclosed |
| US-4716162-A | BRAIN FUNCTION | SANKYO COMPANY, LIMITED (JP) | 1987-12-29 | — | — | US | disclosed |
| EP-0171217-A2 | Fused-ring heterocyclic compounds a process for their production and their pharmaceutical use | SANKYO COMPANY LIMITED (JP) | 1986-02-12 | — | — | EP | disclosed |