Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501243 | 0.89 | METAP2 (0.43) | PHOSPHO1METAP2MEN1KMT2AHTT | |
| SCHEMBL10502578 | 0.83 | METAP2 (0.64) | PHOSPHO1METAP2MEN1KMT2AHTT | |
| SCHEMBL10501162 | 0.83 | NPC1 (0.44) | PHOSPHO1METAP2 | |
| SCHEMBL10502542 | 0.83 | METAP2 (0.43) | PHOSPHO1METAP2 | |
| SCHEMBL10501643 | 0.82 | METAP2 (0.46) | PHOSPHO1METAP2MEN1KMT2AHTT | |
| SCHEMBL10501842 | 0.81 | METAP2 (0.49) | PHOSPHO1METAP2MEN1KMT2AHTT | |
| SCHEMBL10501498 | 0.80 | METAP2 (0.43) | PHOSPHO1METAP2MEN1KMT2AHTT | |
| SCHEMBL10501844 | 0.79 | METAP2 (0.66) | PHOSPHO1METAP2MEN1KMT2AHTT | |
| SCHEMBL10501084 | 0.78 | METAP2 (0.68) | PHOSPHO1METAP2MEN1KMT2ARXFP1 | |
| SCHEMBL10501187 | 0.75 | METAP2 (0.45) | PHOSPHO1METAP2MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |