SCHEMBL10504148

SCHEMBL10504148

Cc1ccc(C(=CCN2CCCC2)c2cccc(C(=O)O)c2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.59
CHRNB4 P30926 1/20 0.59
CHRNA3 P32297 1/20 0.59
CHRNA4 P43681 1/20 0.59
SLC6A4 P31645 3/20 0.57
ADRA1A P35348 2/20 0.57
HRH1 P35367 2/20 0.57
OPRK1 P41145 2/20 0.57
PTGS2 P35354 1/20 0.57
ALDH1A1 P00352 4/20 0.55
LMNA P02545 3/20 0.55
CYP2D6 P10635 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
ADRA2B P18089 2/20 0.55
CHRM1 P11229 1/20 0.55
KCNH2 Q12809 1/20 0.55
TSHR P16473 1/20 0.55
NFKB1 P19838 1/20 0.55
THPO P40225 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10504144 1.00 CHRNB2 (0.59) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10504958 1.00 CHRNB2 (0.59) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10505027 0.90 CHRNB2 (0.60) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10505031 0.90 CHRNB2 (0.60) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10505036 0.90 CHRNB2 (0.60) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10504513 0.87 CHRNB2 (0.52) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10506300 0.84 CHRNB2 (0.55) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10506312 0.84 CHRNB2 (0.55) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10506305 0.84 CHRNB2 (0.55) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4
SCHEMBL10506646 0.84 SLC6A4 (0.65) CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0085959-B1 AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1989-04-19 EP claimed
US-4564685-A ANTIHISTAMINES BURROUGHS WELLCOME CO., A CORP OF NC. 1986-01-14 US claimed
EP-0085959-B1 AROMATIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1989-04-19 EP disclosed
EP-0249950-A1 Aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1987-12-23 EP disclosed
US-4564685-A ANTIHISTAMINES BURROUGHS WELLCOME CO., A CORP OF NC. 1986-01-14 US disclosed
EP-0085959-A2 Aromatic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1983-08-17 EP disclosed