Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 11/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10592625 | 0.98 | ADRB1 (0.55) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10594747 | 0.89 | ADRB1 (0.46) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10504922 | 0.87 | ADRB1 (0.46) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10593669 | 0.86 | ADRB1 (0.47) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10505162 | 0.85 | ADRB1 (0.47) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10504729 | 0.83 | ADRB1 (0.54) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| Fumaric Acid SCHEMBL10503704 | 0.81 | ADRB1 (0.43) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| Fumaric Acid SCHEMBL10504541 | 0.80 | ADRB1 (0.51) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10863230 | 0.79 | ADRB1 (0.46) | ADRB1ADRB2HTR1AOPRK1ADRB3 | |
| SCHEMBL10503765 | 0.78 | ADRB3 (0.40) | ADRB1ADRB2HTR1AOPRK1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |