ADRB1

Beta-1 adrenergic receptor · P08588 · ADRB1 on Sugi Atlas →

242,375 patent compounds predicted against ADRB1, 156,376 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Salmeterol (SCHEMBL4767)	1.00	18/20
Salmeterol (SCHEMBL4768)	1.00	18/20
Salmeterol (SCHEMBL18070)	0.76	18/20
Labetalol (SCHEMBL41230)	1.00	14/20
Protokylol (SCHEMBL50567)	0.76	14/20
Labetalol (SCHEMBL4582)	1.00	13/20
Labetalol (SCHEMBL41231)	1.00	13/20
Oxprenolol (SCHEMBL16310)	1.00	12/20
Oxprenolol (SCHEMBL16311)	1.00	12/20
Indacaterol (SCHEMBL48098)	1.00	10/20
SCHEMBL3391	0.64	10/20
Croconazole (SCHEMBL34369)	0.53	10/20
Croconazole (SCHEMBL36790)	0.52	10/20
Procaterol (SCHEMBL4632)	1.00	9/20
Procaterol (SCHEMBL4633)	1.00	9/20
Alprenolol (SCHEMBL34636)	1.00	9/20
Alprenolol (SCHEMBL34637)	1.00	9/20
SCHEMBL51473	0.48	9/20
Propranolol (SCHEMBL3955)	1.00	8/20
Levopropranolol (SCHEMBL3956)	1.00	8/20

Clinical trials — most relevant to ADRB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome	PHASE3	RECRUITING
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma	PHASE3	COMPLETED
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Safety and Efficacy Study of Carvedilol to Treat Children With Congestive Heart Failure	PHASE3	COMPLETED
Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)	PHASE2	ACTIVE_NOT_RECRUITING
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Biased GRK Signaling Via β2-Adrenergic Receptors in Human Skeletal Muscle	PHASE2	NOT_YET_RECRUITING
Mechanisms for Activation of Beige Adipose Tissue in Humans	PHASE2	RECRUITING
Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation	PHASE1	ACTIVE_NOT_RECRUITING
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Influence of Nebivolol on Postmenopausal Women	nan	UNKNOWN
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Beta-Blockers on Neoadjuvant Immunochemotherapy for Hypertensive Patients With Gastric Cancer	nan	ACTIVE_NOT_RECRUITING
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia	nan	COMPLETED
Comparison of Milrinone and Epinephrine on TAPSE	nan	NOT_YET_RECRUITING
The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF	nan	RECRUITING
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage	nan	NOT_YET_RECRUITING
Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults	nan	ACTIVE_NOT_RECRUITING
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADRB1 binder may also engage these)

Protein	Name	Similarity
Q28998	—	1.000	Q28998 →
P34971	—	1.000	P34971 →
P47899	—	1.000	P47899 →
P18090	—	1.000	P18090 →
Q9TST6	—	0.997	Q9TST6 →
O02666	—	0.996	O02666 →
Q9TT96	—	0.996	Q9TT96 →
P79148	—	0.996	P79148 →
ADRA2C	Alpha-2C adrenergic receptor	0.995	landscape →
Q28927	—	0.994	Q28927 →
P18871	—	0.994	P18871 →
P26255	—	0.993	P26255 →
O02662	—	0.992	O02662 →
Q9TST4	—	0.992	Q9TST4 →
Q60476	—	0.991	Q60476 →
P22086	—	0.989	P22086 →
P22909	—	0.989	P22909 →
Q01338	—	0.989	Q01338 →
Q01337	—	0.989	Q01337 →
ADRA1D	Alpha-1D adrenergic receptor	0.989	landscape →
Q28838	—	0.989	Q28838 →
Q6XXX9	—	0.988	Q6XXX9 →
Q9TTM9	—	0.987	Q9TTM9 →
ADRA2A	Alpha-2A adrenergic receptor	0.987	landscape →
Q6XXY0	—	0.987	Q6XXY0 →
Q8IZ08	—	0.986	Q8IZ08 →
P25115	—	0.986	P25115 →
P97714	—	0.985	P97714 →
P23944	—	0.985	P23944 →
P25962	—	0.985	P25962 →