Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924061 | 0.87 | POLB (0.56) | POLB | |
| SCHEMBL4942431 | 0.87 | TYR (0.57) | POLB | |
| SCHEMBL29904573 | 0.87 | TYR (0.57) | POLB | |
| SCHEMBL6035972 | 0.86 | POLB (0.68) | POLBESR1CYP19A1ESR2NPC1 | |
| SCHEMBL21317665 | 0.85 | POLB (1.00) | POLBESR1CYP19A1ESR2NPC1 | |
| SCHEMBL26046424 | 0.85 | POLB (0.77) | POLBESR1CYP19A1ESR2NPC1 | |
| SCHEMBL2984734 | 0.85 | POLB (0.55) | POLB | |
| SCHEMBL585472 | 0.84 | APLNR (0.56) | POLBNPC1RAB9APKM | |
| SCHEMBL63388 | 0.84 | KMT2A (0.55) | POLBNPC1RAB9A | |
| SCHEMBL20232424 | 0.84 | POLB (0.53) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205264-B1 | CONDENSED SEVEN-MEMBERED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1989-10-18 | — | — | EP | disclosed |
| US-4736031-A | ANTISCHEMIC, ANTICOAGULANTS, HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-04-05 | — | — | US | disclosed |
| EP-0205264-A1 | Condensed seven-membered heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |