APLNR

Apelin receptor · P35414 · APLNR on Sugi Atlas →

60,810 patent compounds predicted against APLNR, 35,351 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL179314	0.53	11/20
SCHEMBL727352	0.49	8/20
SCHEMBL942730	0.52	7/20
SCHEMBL59414	0.50	6/20
Leuprolide (SCHEMBL3174)	0.65	5/20
Leuprolide (SCHEMBL177978)	0.65	5/20
Leuprolide (SCHEMBL570851)	0.65	5/20
Leuprolide (SCHEMBL847084)	0.65	5/20
Histrelin (SCHEMBL17881)	0.60	5/20
Histrelin (SCHEMBL84261)	0.60	5/20
SCHEMBL428462	0.60	5/20
Leuprolide (SCHEMBL1025887)	0.45	5/20
SCHEMBL331120	0.74	4/20
Leuprolide (SCHEMBL4585)	0.65	4/20
Histrelin (SCHEMBL18715)	0.59	4/20
Deslorelin (SCHEMBL59413)	0.56	4/20
Leuprolide (SCHEMBL172917)	0.56	4/20
Deslorelin (SCHEMBL205614)	0.56	4/20
Leuprolide (SCHEMBL713554)	0.55	4/20
Buserelin (SCHEMBL167553)	0.53	4/20

Clinical trials — most relevant to APLNR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Effect of Apelin on Insulin Sensitivity in Type 2 Diabetic Volunteers	PHASE1	COMPLETED
The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects	PHASE1	COMPLETED
Cardiovascular Effects of Apelin In Healthy Volunteers	EARLY_PHASE1	COMPLETED
Relationship Between Apelin and New-onset Atrial Fibrillation After Coronary Artery Bypass Grafting	nan	COMPLETED
Apelin12 in Acne Vulgaris	nan	UNKNOWN
Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD	nan	COMPLETED
Effects of Apelin on the Lung Circulation in Pulmonary Hypertension	nan	UNKNOWN
Determination of Maternal and Neonatal Apelinemia in Obese Women During Pregnancy	nan	COMPLETED
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation	nan	COMPLETED
Interaction of Apelin and Angiotensin in the Systemic Circulation	nan	COMPLETED
Uterine Artery Diastolic Notching & Apelin-13 and 36	nan	COMPLETED
Relation Between Plasma Apelin Level and Diabetic Nephropathy in Type 2 Diabetes Patients.	nan	COMPLETED
Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).	nan	COMPLETED
Apelin as a Marker of Early Complications in Type 1 Diabetes Mellitus	nan	UNKNOWN
Apelin as a Potential Treatment for Chronic Kidney Disease	nan	COMPLETED
eMESH Struct. 2022-23	nan	UNKNOWN
Haemodynamic Effects of Apelin Agonists and Antagonists in Man in COPD With Raised Pulmonary Artery Pressures	nan	COMPLETED
The Role of Adipokines In Atrial Fibrillation	nan	UNKNOWN
Interaction of Apelin and Angiotensin in the Human Forearm Circulation	nan	COMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Affective Touch, Hedonia and Suicidal Behavior	nan	COMPLETED
Clinical Study Evaluating the Effect of Losartan	nan	RECRUITING
Eating Behaviour in Crohn's Disease	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.	nan	UNKNOWN
Analysis of Cardiac Biomarker Racial Discrepancies	nan	ENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a APLNR binder may also engage these)

Protein	Name	Similarity
Q9WV08	—	1.000	Q9WV08 →
O97666	—	1.000	O97666 →
Q9JHG3	—	0.999	Q9JHG3 →
P56412	—	0.984	P56412 →
E9QJ73	—	0.984	E9QJ73 →
Q0VDU3	—	0.983	Q0VDU3 →
Q9Z0Z6	—	0.983	Q9Z0Z6 →
P35374	—	0.982	P35374 →
Q9BG77	—	0.982	Q9BG77 →
P35351	—	0.982	P35351 →
O97663	—	0.981	O97663 →
P49685	—	0.981	P49685 →
O18982	—	0.980	O18982 →
Q8MJ89	—	0.980	Q8MJ89 →
Q28003	—	0.980	Q28003 →
MCHR2	Melanin-concentrating hormone receptor 2	0.979	landscape →
Q2YEG0	—	0.979	Q2YEG0 →
P55920	—	0.979	P55920 →
P32303	—	0.979	P32303 →
P43142	—	0.978	P43142 →
Q9BDS7	—	0.978	Q9BDS7 →
P97639	—	0.978	P97639 →
B0UXR0	—	0.978	B0UXR0 →
Q2YEF9	—	0.978	Q2YEF9 →
CXCR1	C-X-C chemokine receptor type 1	0.978	landscape →
CXCR2	C-X-C chemokine receptor type 2	0.978	landscape →
MCHR1	Melanin-concentrating hormone receptor 1	0.977	landscape →
P31392	—	0.977	P31392 →
Q9BDS8	—	0.977	Q9BDS8 →
P35411	—	0.977	P35411 →