Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.32 |
| ▸ | SLC2A9 | Q9NRM0 | 2/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9511662 | 0.88 | ESR1 (0.33) | AKT1CYP1A1ESR1ESR2KDM4E | |
| SCHEMBL9511741 | 0.84 | ESR1 (0.32) | AKT1ESR1ESR2KDM4ESLC22A12 | |
| SCHEMBL10504291 | 0.84 | SRD5A1 (0.38) | AKT1LTB4RLTB4R2 | |
| SCHEMBL10368416 | 0.84 | LTB4R (0.41) | AKT1CYP1A1ESR1ESR2KDM4E | |
| SCHEMBL10408545 | 0.83 | AKT1 (0.39) | AKT1CYP1A1ESR1ESR2KDM4E | |
| SCHEMBL10504901 | 0.82 | AKT1 (0.38) | AKT1CYP1A1ESR1ESR2KDM4E | |
| SCHEMBL9821761 | 0.81 | AKT1 (0.38) | AKT1CYP1A1ESR1ESR2KDM4E | |
| SCHEMBL10504280 | 0.81 | AKT1 (0.38) | AKT1CYP1A1ESR1ESR2KDM4E | |
| SCHEMBL10371731 | 0.80 | AKT1 (0.39) | AKT1CYP1A1KDM4EALDH1A1SLC22A12 | |
| SCHEMBL10408575 | 0.80 | ESR1 (0.35) | AKT1CYP1A1ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163284-B1 | SUBSTITUTED CHROMANON-2-YL ALKANOLS AND DERIVATIVES THEREOF | G.D. Searle & Co. (US) | 1989-01-04 | — | — | EP | disclosed |
| EP-0163284-A2 | Substituted chromanon-2-yl alkanols and derivatives thereof | G.D. Searle & Co. (US) | 1985-12-04 | — | — | EP | disclosed |
| US-4546194-A | Substituted chromanon-2-yl alkanols and derivatives thereof | G. D. SEARLE & CO. (US) | 1985-10-08 | — | — | US | disclosed |