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LTB4R

Leukotriene B4 receptor 1 · Q15722 · LTB4R on Sugi Atlas →

55,914 patent compounds predicted against LTB4R, 28,006 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL200343 SCHEMBL200343 0.89 20/20
SCHEMBL202000 SCHEMBL202000 0.89 20/20
SCHEMBL201047 SCHEMBL201047 0.88 20/20
SCHEMBL200708 SCHEMBL200708 0.87 20/20
SCHEMBL201167 SCHEMBL201167 0.87 20/20
SCHEMBL200666 SCHEMBL200666 0.87 20/20
SCHEMBL200665 SCHEMBL200665 0.86 20/20
SCHEMBL203825 SCHEMBL203825 0.86 20/20
SCHEMBL201936 SCHEMBL201936 0.86 20/20
SCHEMBL200668 SCHEMBL200668 0.86 20/20
SCHEMBL201262 SCHEMBL201262 0.86 20/20
SCHEMBL202060 SCHEMBL202060 0.86 20/20
SCHEMBL200437 SCHEMBL200437 0.85 20/20
SCHEMBL200698 SCHEMBL200698 0.85 20/20
SCHEMBL200397 SCHEMBL200397 0.85 20/20
SCHEMBL200832 SCHEMBL200832 0.85 20/20
SCHEMBL200405 SCHEMBL200405 0.83 20/20
SCHEMBL200686 SCHEMBL200686 0.83 20/20
SCHEMBL201366 SCHEMBL201366 0.83 20/20
SCHEMBL309266 SCHEMBL309266 0.83 20/20

Clinical trials — most relevant to LTB4R by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Open-label Study of the Effects of Montelukast in Patients With Chronic Cough PHASE4COMPLETED
Predicting Response to Standardized Pediatric Colitis Therapy PHASE4COMPLETED
TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast) PHASE4COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite PHASE2/PHASE3WITHDRAWN
Montelukast in Parkinson Disease PHASE2/PHASE3RECRUITING
Aspirin for Uncontrolled Asthma PHASE3COMPLETED
Montelukast for Early Life Wheezing PHASE2/PHASE3COMPLETED
Serum Intercellular Adhesion Molecule -1 in Acne Vulgaris Patients : Effect of Montelukast PHASE3UNKNOWN
Predicting the Response to Montelukast by Genetic Variation in Asthmatics PHASE3COMPLETED
GSK2190915 Neutrophilic Asthma Study PHASE2COMPLETED
Treatment of Bronchial Asthma With Borage and Echium Seed Oils PHASE1/PHASE2COMPLETED
Investigation the Effect of Montelukast in COVID-19 PHASE2UNKNOWN
Treating Exacerbations of Asthma With Oral Montelukast in Children PHASE2COMPLETED
Comparative Effects of Fish Oil Supplementation and a Montelukast on EIB and Airway Inflammation in Asthma PHASE1COMPLETED
A Single Dose Study to Assess the Regional Absorption and Bioavailability of 100mg GSK2190915A PHASE1COMPLETED
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial) EARLY_PHASE1RECRUITING
Impact Of Montelukast On Allergic Rhinitis And Its Inflammatory Makers EARLY_PHASE1UNKNOWN
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing nanUNKNOWN
The Effectiveness of Montelukast on Atopic Dermatitis in Koreans nanCOMPLETED
The Severe Asthma Research Program III-Boston Clinical Site nanCOMPLETED
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses nanCOMPLETED
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma nanUNKNOWN
Modification of Allergic Immunologic Response by Leukotriene Antagonists - Ancillary to ACRN IMPACT nanCOMPLETED
Leukotriene Polymorphisms and Montelukast Response - Ancillary to LoDo Trial nanCOMPLETED
Effect of Montelukast on the Expression and Variation of TGF-β for Children With Mild Persistent Asthma nanCOMPLETED
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B nanCOMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
Montelukast in the Treatment of Duodenal Eosinophilia nanCOMPLETED
Gender Differences and SNPs in Asthmatic Patients nanUNKNOWN
Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a LTB4R binder may also engage these)

ProteinNameSimilarity
Q3T181 — 1.000 Q3T181 →
Q9R0Q2 — 0.996 Q9R0Q2 →
O88855 — 0.996 O88855 →
Q9JJL9 — 0.988 Q9JJL9 →
Q924U0 — 0.987 Q924U0 →
Q5KSK8 — 0.985 Q5KSK8 →
LTB4R2 Leukotriene B4 receptor 2 0.984 landscape →
Q9BDQ5 — 0.979 Q9BDQ5 →
Q8HZN9 — 0.977 Q8HZN9 →
Q867B2 — 0.977 Q867B2 →
P48748 — 0.977 P48748 →
Q9JL21 — 0.976 Q9JL21 →
O88410 — 0.976 O88410 →
Q9JII9 — 0.976 Q9JII9 →
Q8HYC3 — 0.975 Q8HYC3 →
GPR35 G-protein coupled receptor 35 0.975 landscape →
CXCR3 C-X-C chemokine receptor type 3 0.974 landscape →
Q8HZP1 — 0.973 Q8HZP1 →
Q5MD61 — 0.973 Q5MD61 →
Q61125 — 0.972 Q61125 →
CCR10 C-C chemokine receptor type 10 0.971 landscape →
Q8BUD0 — 0.968 Q8BUD0 →
P50132 — 0.967 P50132 →
UTS2R Urotensin-2 receptor 0.967 landscape →
P97583 — 0.967 P97583 →
Q8HZP3 — 0.966 Q8HZP3 →
Q1JQB3 — 0.966 Q1JQB3 →
GPR4 G-prodeshotein coupled receptor 4 0.966 landscape →
P49220 — 0.966 P49220 →
Q95L01 — 0.965 Q95L01 →