Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | MTOR | P42345 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045082 | 0.95 | MEN1 (0.68) | MEN1KMT2AATMCYP3A4TP53 | |
| Bromide SCHEMBL10837938 | 0.94 | MEN1 (0.66) | MEN1KMT2AATMCYP3A4TP53 | |
| SCHEMBL9263335 | 0.94 | MEN1 (0.66) | MEN1KMT2AATMCYP3A4TP53 | |
| SCHEMBL8535355 | 0.94 | MEN1 (0.66) | MEN1KMT2AATMCYP3A4TP53 | |
| SCHEMBL19390253 | 0.83 | CYP19A1 (0.71) | CYP19A1ALDH1A1HMOX1TBXAS1 | |
| SCHEMBL10645328 | 0.82 | MAPT (0.56) | MEN1KMT2AATMCYP3A4TP53 | |
| SCHEMBL8543266 | 0.82 | CYP3A4 (0.52) | MEN1KMT2AATMCYP3A4TP53 | |
| SCHEMBL12045347 | 0.82 | HMOX1 (0.84) | KMT2ACYP19A1HMOX1TBXAS1 | |
| SCHEMBL14416015 | 0.82 | MEN1 (0.61) | MEN1KMT2AATMCYP3A4TP53 | |
| SCHEMBL4539675 | 0.81 | TP53 (0.69) | MEN1KMT2ACYP3A4TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863944-A | Dopamine-β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0125783-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-04 | — | — | EP | disclosed |
| US-4772723-A | Dopamine β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1988-09-20 | — | — | US | disclosed |
| US-4532331-A | 1-Benzyl-2-aminomethyl imidazole derivatives | SMITHKLINE BECKMAN CORPORATION (US) | 1985-07-30 | — | — | US | disclosed |
| EP-0125783-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-21 | — | — | EP | disclosed |