SCHEMBL10508252

SCHEMBL10508252

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2S(=O)(=O)N(C)C)n1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.58
CDK1 P06493 1/20 0.56
MAPT P10636 3/20 0.47
TP53 P04637 1/20 0.47
GLA P06280 1/20 0.47
CYP1A2 P05177 1/20 0.45
KMT2A Q03164 1/20 0.43
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11086619 0.93 GAA (0.51) GAACDK1MAPTTP53GLA
SCHEMBL10363991 0.92 GAA (0.50) GAACDK1MAPTTP53GLA
SCHEMBL8444621 0.92 GAA (0.58) GAACDK1MAPTTP53GLA
SCHEMBL10616134 0.92 GAA (0.67) GAACDK1MAPTTP53GLA
SCHEMBL10736294 0.91 GAA (0.56) GAACDK1MAPTTP53GLA
SCHEMBL11086097 0.91 GAA (0.56) GAACDK1MAPTTP53GLA
SCHEMBL9788640 0.90 GAA (0.47) GAACDK1MAPTTP53GLA
SCHEMBL9826164 0.89 GAA (0.59) GAACDK1MAPTTP53GLA
SCHEMBL11092594 0.89 GAA (0.54) GAACDK1MAPTTP53GLA
SCHEMBL11082739 0.88 GAA (0.55) GAACDK1MAPTTP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0094260-B1 HERBICIDAL HETEROCYCLIC ALKYLAMINOCARBONYLSULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-03-22 EP claimed
EP-0117014-B1 HERBICIDAL N-HYDROXY-N'-SULFONYLGUANIDINES AND SULFONAMIDE INNER SALTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-07-06 EP claimed
US-4484939-A PRE-AND POST-EMERGENCE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-11-27 US claimed
EP-0117014-A1 Herbicidal N-hydroxy-N'-sulfonylguanidines and sulfonamide inner salts E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-08-29 EP claimed
EP-0023141-B1 HERBICIDAL SULFONAMIDES, PREPARATION AND USE THEREOF, COMPOSITIONS CONTAINING THEM, INTERMEDIATES THEREFOR AND PREPARATION OF SUCH INTERMEDIATES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-11 EP claimed
EP-0094260-A2 Herbicidal heterocyclic alkylaminocarbonylsulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-11-16 EP claimed
US-4310346-A HERBICIDES AND PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-01-12 US claimed
EP-0023141-A2 Herbicidal sulfonamides, preparation and use thereof, compositions containing them, intermediates therefor and preparation of such intermediates E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-01-28 EP claimed
EP-0117014-B1 HERBICIDAL N-HYDROXY-N'-SULFONYLGUANIDINES AND SULFONAMIDE INNER SALTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-07-06 EP disclosed
US-4604133-A Herbicidal sulfonamide inner salts E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-08-05 US disclosed
US-4484939-A PRE-AND POST-EMERGENCE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-11-27 US disclosed
EP-0117014-A1 Herbicidal N-hydroxy-N'-sulfonylguanidines and sulfonamide inner salts E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-08-29 EP disclosed
EP-0023141-B1 HERBICIDAL SULFONAMIDES, PREPARATION AND USE THEREOF, COMPOSITIONS CONTAINING THEM, INTERMEDIATES THEREFOR AND PREPARATION OF SUCH INTERMEDIATES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-11 EP disclosed
US-4310346-A HERBICIDES AND PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-01-12 US disclosed
EP-0023141-A2 Herbicidal sulfonamides, preparation and use thereof, compositions containing them, intermediates therefor and preparation of such intermediates E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-01-28 EP disclosed