Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.56 |
| ▸ | PNP | P00491 | 6/20 | 0.55 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.51 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506664 | 0.88 | PNP (0.60) | TYMSPNPXDHHPRT1 | |
| SCHEMBL10506827 | 0.85 | PNP (0.60) | TYMSPNPXDHHPRT1TLR7 | |
| SCHEMBL10506494 | 0.84 | PNP (0.58) | TYMSPNPXDHHPRT1 | |
| SCHEMBL10506260 | 0.84 | PNP (0.58) | TYMSPNPHPRT1 | |
| SCHEMBL2128391 | 0.84 | PNP (0.76) | TYMSPNPXDHHPRT1TLR7 | |
| SCHEMBL10506462 | 0.81 | PNP (0.58) | TYMSPNPXDHHPRT1TLR7 | |
| SCHEMBL3395173 | 0.81 | TRAP1 (0.58) | TYMSHSP90B1TRAP1NPC1JAK2 | |
| SCHEMBL10507177 | 0.78 | PNP (0.54) | TYMSPNPXDHHPRT1KMT2A | |
| SCHEMBL8145519 | 0.78 | PNP (0.72) | TYMSPNPXDH | |
| Hydrochloric Acid SCHEMBL17186455 | 0.77 | PNP (0.70) | TYMSPNPXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | claimed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | claimed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | claimed |
| US-4874862-A | Process for preparing guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | disclosed |