SCHEMBL10508387

SCHEMBL10508387

COC(=O)c1c(NC(C)(C)C)n[nH]c1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.44
CSNK2A2 P19784 1/20 0.44
KDR P35968 1/20 0.44
CSNK2B P67870 1/20 0.44
CSNK2A1 P68400 1/20 0.44
HSP90AA1 P07900 1/20 0.43
HSP90AB1 P08238 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
PDE4D Q08499 1/20 0.41
KMT2A Q03164 3/20 0.40
LMNA P02545 2/20 0.40
AURKA O14965 2/20 0.38
MAPT P10636 4/20 0.38
POLB P06746 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
F2 P00734 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KDM4E B2RXH2 1/20 0.35
AR P10275 1/20 0.35
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10488639 0.86 PDE4D (0.61) GAASMN1; SMN2PDE4DKMT2AAURKA
SCHEMBL11149734 0.85 SMN1; SMN2 (0.46) GAACSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL10488591 0.83 HCAR2 (0.38) GAACSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL4754626 0.76 PDE4D (0.66) GAACSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL11084510 0.73 SMN1; SMN2 (0.48) GAACSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL10488606 0.72 PDE4D (0.55) GAASMN1; SMN2PDE4DKMT2AAURKA
SCHEMBL10978593 0.72 SMN1; SMN2 (0.50) GAACSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL10675567 0.72 SMN1; SMN2 (0.53) GAACSNK2A2CSNK2BCSNK2A1HSP90AA1
SCHEMBL11327493 0.72 SMN1; SMN2 (0.44) GAACSNK2A2KDRCSNK2BCSNK2A1
SCHEMBL11472383 0.72 GAA (0.49) GAACSNK2A2KDRCSNK2BCSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0002180-A1 Substituted 3-aminopyrazoles, herbicides containing them and method for controlling undesirable growth of plants BASF Aktiengesellschaft (DE) 1979-06-13 EP claimed
EP-0121129-B1 2,5-DIHYDRO-5-ARYLIMINO-PYRROLES, PROCESS FOR THEIR PRODUCTION AND THEIR USES AS HERBICIDES BASF Aktiengesellschaft (DE) 1989-02-01 EP disclosed
US-4789747-A BROAD LEAF PLANTS, GRASSES, WEEDS BASF AKTIENGESELLSCHAFT (DE) 1988-12-06 US disclosed
US-4744812-A HALOGENATED DIPHENYL ETHER BASF AKTIENGESELLSCHAFT (DE) 1988-05-17 US disclosed
US-4632696-A POSTEMERGENCE, PREEMERGENCE APPLICATIONS BASF AKTIENGESELLSCHAFT (DE) 1986-12-30 US disclosed
EP-0115808-B1 CYCLOHEXAN-1,3-DIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES BASF Aktiengesellschaft (DE) 1986-08-20 EP disclosed
EP-0084665-B1 THIADIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE IN COMBATTING UNWANTED PLANT GROWTH BASF Aktiengesellschaft (DE) 1986-08-13 EP disclosed
US-4585881-A 2,5-dihydro-5-aryliminopyrrole derivatives and their preparation BASF AKTIENGESELLSCHAFT (DE) 1986-04-29 US disclosed
US-4568383-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1986-02-04 US disclosed
EP-0053679-B1 DIPHENYL ETHER, PREPARATION AND USE AS HERBICIDE BASF Aktiengesellschaft (DE) 1986-01-22 EP disclosed
US-4316039-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US disclosed
EP-0042991-A1 Carbonyl-amino-urethanes and herbicidal and fungicidal compositions containing them BASF Aktiengesellschaft (DE) 1982-01-06 EP disclosed
EP-0041613-A1 Derivatives of aralkylaniline and herbicides containing these compounds BASF Aktiengesellschaft (DE) 1981-12-16 EP disclosed
EP-0041145-A2 Aralkyl-phenyl ureas and their herbicidal compositions BASF Aktiengesellschaft (DE) 1981-12-09 EP disclosed
EP-0037925-A1 Substituted pyridazinones, process for their preparation, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1981-10-21 EP disclosed
EP-0035712-A1 N-aryl(thiol) carbamates, process for their preparation and their use in combating undesired plant growth BASF Aktiengesellschaft (DE) 1981-09-16 EP disclosed
EP-0032242-A1 4H-3,1-benzoxazine derivatives, process for their preparation and their use in inhibiting the growth of unwanted plants BASF Aktiengesellschaft (DE) 1981-07-22 EP disclosed
EP-0027915-A1 Herbicidal agents based on diphenyl ethers and benzothiadiazinone dioxides or pyridinothiadiazinone dioxides, and their use BASF Aktiengesellschaft (DE) 1981-05-06 EP disclosed
US-4260775-A Substituted 3-aminopyrazoles BASF AKTIENGESELLSCHAFT (DE) 1981-04-07 US disclosed
EP-0002180-A1 Substituted 3-aminopyrazoles, herbicides containing them and method for controlling undesirable growth of plants BASF Aktiengesellschaft (DE) 1979-06-13 EP disclosed