Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11170521 | 0.82 | ROCK1 (0.46) | PARP1KDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2463881 | 0.82 | PARP1 (0.45) | PARP1CSNK2A1KDM4ERECQLLMNA | |
| SCHEMBL27384820 | 0.82 | POLB (0.46) | KDM4EPRKAG1PRKAA1PRKAB1KMT2A | |
| SCHEMBL2462240 | 0.82 | PARP1 (0.45) | PARP1CSNK2A1KDM4ERECQLLMNA | |
| SCHEMBL29735258 | 0.82 | ALDH1A1 (0.49) | PARP1KDM4EPRKAA1LMNAKMT2A | |
| SCHEMBL23098990 | 0.82 | ALDH1A1 (0.49) | PARP1KDM4EPRKAA1LMNAKMT2A | |
| SCHEMBL2446205 | 0.79 | KDM4E (0.65) | PARP1KDM4ELMNAKMT2AALDH1A1 | |
| SCHEMBL4055439 | 0.79 | PARP1 (0.42) | PARP1CSNK2A1KDM4ERECQLLMNA | |
| SCHEMBL2463004 | 0.79 | MAP2K4 (0.44) | PARP1CSNK2A1KDM4ERECQLALDH1A1 | |
| SCHEMBL19328981 | 0.78 | PARP1 (0.48) | PARP1CSNK2A1KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164593-B1 | ANTI-INFLAMMATORY PHTHALAZINONES | FISONS CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0164593-A1 | Anti-inflammatory phthalazinones | FISONS CORPORATION (US) | 1985-12-18 | — | — | EP | disclosed |