Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508847 | 0.87 | TYMS (0.51) | HPRT1CMA1XDHTYMS | |
| SCHEMBL10506935 | 0.84 | MAPT (0.50) | HPRT1XDHKMT2AMEN1DAO | |
| SCHEMBL10506917 | 0.81 | HPRT1 (0.47) | HPRT1XDHMAPTTYMS | |
| SCHEMBL9798195 | 0.79 | HPRT1 (0.47) | HPRT1PKMALDH1A1MAPK1SIRT2 | |
| SCHEMBL10506884 | 0.78 | HPRT1 (0.48) | HPRT1XDHALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10507629 | 0.78 | PNP (0.50) | HPRT1KMT2AMEN1ALDH1A1DAO | |
| SCHEMBL10506525 | 0.78 | MTNR1A (0.47) | MTNR1AMTNR1BCMA1XDHKMT2A | |
| SCHEMBL10507502 | 0.78 | TYMS (0.51) | HPRT1XDHKMT2ADAOTYMS | |
| SCHEMBL9663161 | 0.77 | HPRT1 (0.41) | HPRT1XDHKMT2AMEN1KDM4E | |
| SCHEMBL10507190 | 0.77 | HPRT1 (0.47) | MTNR1AMTNR1BHPRT1CMA1XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874862-A | Process for preparing guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | disclosed |