Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515680 | 0.80 | PDE3A (0.54) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| Olprinone SCHEMBL19205852 | 0.77 | PDE3A (1.00) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| Olprinone SCHEMBL27661 | 0.77 | PDE3A (1.00) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| Olprinone SCHEMBL563912 | 0.76 | HPGD (1.00) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| Olprinone SCHEMBL6052374 | 0.76 | HPGD (1.00) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| Olprinone SCHEMBL27901698 | 0.76 | PDE3A (0.98) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| SCHEMBL27273901 | 0.76 | DYRK1A (0.57) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| SCHEMBL10513551 | 0.75 | CYP3A4 (0.61) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| SCHEMBL10512816 | 0.75 | PIK3CD (0.49) | PDE4APDE3AHPGDCYP3A4NFKB1 | |
| SCHEMBL10512080 | 0.75 | PDE3A (0.74) | PDE4APDE3AHPGDCYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199127-B1 | 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative | Eisai Co., Ltd. (JP) | 1989-12-13 | — | — | EP | disclosed |
| US-4803276-A | CARDIOTONIC AGENTS, VASODILATION | EISAI CO., LTD. (JP) | 1989-02-07 | — | — | US | disclosed |
| US-4791202-A | CARDIOTONIC AGENTS; CONGESTIVE HEART FAILURE | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4791203-A | CARDIOTONIC AGENTS | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4751227-A | 3-cyano-5-(6-imidazo[1,2-a]pyridyl)pyridin-2-ols useful as cardiotonics | EISAI CO., LTD. (JP) | 1988-06-14 | — | — | US | disclosed |
| EP-0199127-A1 | 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative | Eisai Co., Ltd. (JP) | 1986-10-29 | — | — | EP | disclosed |