Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Olprinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 6/20 | 0.98 |
| ▸ | PDE4A | P27815 | 2/20 | 0.98 |
| ▸ | HPGD | P15428 | 3/20 | 0.96 |
| ▸ | BLM | P54132 | 2/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.96 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olprinone SCHEMBL19205852 | 0.99 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL27661 | 0.99 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL6052374 | 0.98 | HPGD (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL563912 | 0.98 | HPGD (1.00) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL931814 | 0.94 | PDE3A (0.90) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL28068934 | 0.87 | PDE3A (0.77) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10512080 | 0.84 | PDE3A (0.74) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10514600 | 0.81 | PDE3A (0.70) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL9460929 | 0.81 | PDE3A (0.70) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10573731 | 0.81 | PDE3A (0.69) | PDE3APDE4AHPGDBLMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114773341-A | Preparation method of olprinone hydrochloride | 河北爱尔海泰制药有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-109575017-A | A kind of preparation method of Olprinone HCl compound | 山东蒲济医药科技有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-106349246-A | Preparation method of olprinone and 9-azaindole-5-boric acid | 山东百诺医药股份有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-103087059-B | Preparation method for high-purity olprinone hydrochloride | HEBEI ZHITONG PHARMACEUTICAL GROUP CO LTD | 2014-12-10 | — | — | CN | disclosed |
| CN-103087059-A | Preparation method for high-purity olprinone hydrochloride | HEBEI ZHITONG MEDICAL HOLDING GROUP CO LTD | 2013-05-08 | — | — | CN | disclosed |