Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447424 | 0.87 | MAPT (0.56) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10516434 | 0.82 | CYP3A4 (0.53) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL25328717 | 0.81 | CSNK2A2 (0.65) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL30523094 | 0.80 | MAPT (0.72) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL25327302 | 0.80 | MAPT (0.72) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10669621 | 0.78 | MAPT (0.57) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL27405000 | 0.78 | CYP3A4 (0.79) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10515883 | 0.77 | KDM4E (0.56) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10515296 | 0.77 | MAPT (0.56) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10516555 | 0.77 | ALDH1A1 (0.69) | KMT2AMAPTCYP3A4ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183169-B1 | HALOGEN-HYDROXY FLAVONE | MERCK PATENT GmbH (DE) | 1989-05-10 | — | — | EP | disclosed |
| US-4788215-A | TREATMENT OF HYPERTHYROIDISM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-11-29 | — | — | US | disclosed |
| US-4713465-A | Flavanone intermediates for halogenohydroxyflavones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-12-15 | — | — | US | disclosed |
| EP-0183169-A2 | Halogen-hydroxy flavone | MERCK PATENT GmbH (DE) | 1986-06-04 | — | — | EP | disclosed |