Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.64 |
| ▸ | SPHK2 | Q9NRA0 | 9/20 | 0.64 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257009 | 1.00 | SPHK1 (0.64) | SPHK1SPHK2OPRD1GBA1 | |
| SCHEMBL6342866 | 1.00 | SPHK1 (0.64) | SPHK1SPHK2OPRD1GBA1 | |
| SCHEMBL2169692 | 0.95 | SPHK1 (0.69) | SPHK1SPHK2 | |
| SCHEMBL4926619 | 0.95 | SPHK1 (0.69) | SPHK1SPHK2 | |
| SCHEMBL312540 | 0.95 | SPHK1 (0.69) | SPHK1SPHK2 | |
| Acetic Acid SCHEMBL7448428 | 0.93 | OPRD1 (0.59) | SPHK1SPHK2OPRD1 | |
| SCHEMBL19823120 | 0.91 | SPHK1 (0.58) | SPHK1SPHK2 | |
| Biphenyl SCHEMBL27478734 | 0.90 | SPHK1 (0.64) | SPHK1SPHK2 | |
| SCHEMBL7576557 | 0.88 | GBA1 (0.59) | SPHK1SPHK2GBA1 | |
| SCHEMBL17141385 | 0.88 | GBA1 (0.59) | SPHK1SPHK2GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111100063-B | Preparation method for synthesizing 2-fluoromethyl substituted pyrrolidine, piperidine and piperazine derivatives | 南京药石科技股份有限公司 | 2022-05-17 | — | — | CN | disclosed |
| EP-3970723-A1 | AMINOINDANE COMPOUNDS FOR USE IN TREATING UROLOGICAL PAIN | Asana BioSciences, LLC (US) | 2022-03-23 | — | — | EP | disclosed |
| EP-3363437-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS SOLUTIONS (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-3363437-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS SOLUTIONS (US) | 2021-07-28 | — | — | EP | disclosed |
| CN-107540599-B | Aminoindane compounds and their use to treat pain | 阿萨纳生物科技有限责任公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-111100063-A | Preparation method for synthesizing 2-fluoromethyl substituted pyrrolidine, piperidine and piperazine derivatives | 南京药石科技股份有限公司 | 2020-05-05 | — | — | CN | disclosed |
| EP-3363437-A1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | Endo Pharmaceuticals Solutions Inc. (US) | 2018-08-22 | — | — | EP | disclosed |
| EP-2675787-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS INC (US) | 2018-03-28 | — | — | EP | disclosed |
| EP-2675787-B1 | AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN | ENDO PHARMACEUTICALS INC (US) | 2018-03-28 | — | — | EP | disclosed |
| US-9375423-B2 | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis | ASANA BIOSCIENCES, LLC (US) | 2016-06-28 | — | — | US | disclosed |
| EP-0723537-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010513-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1995-04-20 | — | — | WO | disclosed |
| EP-0063365-B2 | 1,4-Dihydropyridine derivative and pharmaceutical composition containing same | KYOWA HAKKO KOGYO KK (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5169855-A | PIPERIDINE ETHER DERIVATIVES AS PSYCHOTROPIC DRUGS OR PLANT FUNGICIDES | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-12-08 | — | — | US | disclosed |
| US-5124324-A | Psychological disorders, 5-hydroxy tryptamine antagonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-06-23 | — | — | US | disclosed |
| EP-0449187-A2 | Piperidin ether derivatives as psychotropic drugs or plant fungicides | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |
| EP-0429984-A2 | Indole derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |
| EP-0063365-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |
| US-4448964-A | HYPOTENSIVE AGENTS; VASODILATORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1984-05-15 | — | — | US | disclosed |
| EP-0063365-A1 | 1,4-Dihydropyridine derivative and pharmaceutical composition containing same | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-10-27 | — | — | EP | disclosed |