OPRD1

Delta-type opioid receptor · P41143 · OPRD1 on Sugi Atlas →

373,310 patent compounds predicted against OPRD1, 221,527 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Butorphanol (SCHEMBL41926)	0.83	16/20
Butorphanol (SCHEMBL3749)	1.00	14/20
Cyclazocine (SCHEMBL37996)	1.00	14/20
Alvimopan (SCHEMBL49578)	1.00	14/20
Hydrocodone (SCHEMBL2987)	1.00	12/20
Nalmefene (SCHEMBL35230)	1.00	12/20
SCHEMBL45924	1.00	12/20
Dihydrocodeine (SCHEMBL24607)	0.77	12/20
Thebacon (SCHEMBL25766)	0.63	12/20
Morphine (SCHEMBL2997)	1.00	11/20
Morphine (SCHEMBL29316)	1.00	11/20
Morphine (SCHEMBL29317)	1.00	11/20
SCHEMBL46197	1.00	11/20
Morphine (SCHEMBL40902)	0.98	11/20
SCHEMBL46231	0.93	11/20
Levallorphan (SCHEMBL34060)	0.86	11/20
Enkephalin (SCHEMBL30857)	0.75	11/20
SCHEMBL46193	0.52	11/20
SCHEMBL46228	0.48	11/20
Thebaine (SCHEMBL37580)	0.46	11/20

Clinical trials — most relevant to OPRD1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery	PHASE4	NOT_YET_RECRUITING
Oliceridine in Patients With Acute Burn Injuries	PHASE4	COMPLETED
Targeted Naltrexone for Problem Drinkers	PHASE4	COMPLETED
Morphine vs. Oxycodone for Postoperative Pain Management	PHASE4	COMPLETED
Anti-suicidal Effects of Buprenorphine in Opioid Use Disorder	PHASE4	WITHDRAWN
Population Pharmacokinetics and Pharmacogenomics of Oral Oxycodone in Thai Pediatric Surgical Patients	PHASE4	UNKNOWN
Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain	PHASE4	SUSPENDED
Colonic Motor Patterns in Healthy Volunteers	PHASE4	COMPLETED
The Effects of Oxycodone Versus Sufentanil on Pain and Inflammatory Response After TACE	PHASE4	COMPLETED
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery	PHASE4	RECRUITING
Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia	PHASE4	WITHDRAWN
Nalbuphine in ARDS Patients After Surgery	PHASE4	RECRUITING
Buprenorphine for Treatment Resistant Depression	PHASE3	COMPLETED
Postoperative Pain After Orthopedic Surgery: Does it Help to Give Fentanyl Before Start of Remifentanil Based Anesthesia?	PHASE3	COMPLETED
Genetic Effects on Dopamine Response to an Opiate	PHASE2	COMPLETED
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans	PHASE2	COMPLETED
Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans	PHASE2	COMPLETED
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.	PHASE2	NOT_YET_RECRUITING
Naltrexone for Individuals of East Asian Descent	PHASE2	COMPLETED
Paravertebral Morphine Versus Dexmedetomidine on Acute and Chronic Postmastectomy Pain	PHASE1/PHASE2	UNKNOWN
Brain Dopaminergic Signaling in Opioid Use Disorders	EARLY_PHASE1	COMPLETED
Analgesia Effects of Nalbuphine vs Sulfentanil	nan	UNKNOWN
Patient Controlled Analgesia Pharmacogenetic Study	nan	COMPLETED
Impact of Delta Opioid Receptor Gene (OPRD1) Variations on Treatment Outcome in African Americans	nan	COMPLETED
Multicenter Perioperative Opioid Pharmacogenetic Study	nan	COMPLETED
Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain	nan	NOT_YET_RECRUITING
A Study of Genetic Variation Influencing Pain and Response to Opioid Medications	nan	WITHDRAWN
a Small Dose of Naloxone,Minimize Intrathecal Morphine Side Effects	nan	COMPLETED
Pharmacogenetic Morphine Spine Study	nan	COMPLETED
Determining Genetic Biomarkers Predictive of the Development of Prescription Opioid Addiction	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a OPRD1 binder may also engage these)

Protein	Name	Similarity
P33533	—	1.000	P33533 →
P32300	—	1.000	P32300 →
P79292	—	0.980	P79292 →
P35377	—	0.976	P35377 →
OPRL1	Nociceptin receptor	0.976	landscape →
P35370	—	0.973	P35370 →
P41144	—	0.971	P41144 →
P47748	—	0.970	P47748 →
OPRK1	Kappa-type opioid receptor	0.967	landscape →
F1MV99	—	0.965	F1MV99 →
Q2KIP6	—	0.962	Q2KIP6 →
P42866	—	0.962	P42866 →
O08858	—	0.959	O08858 →
Q5IS84	—	0.959	Q5IS84 →
P34975	—	0.959	P34975 →
Q5IS39	—	0.959	Q5IS39 →
P30938	—	0.958	P30938 →
P33535	—	0.957	P33535 →
Q49LX5	—	0.957	Q49LX5 →
P33534	—	0.956	P33534 →
SSTR1	Somatostatin receptor type 1	0.954	landscape →
OPRM1	Mu-type opioid receptor	0.953	landscape →
Q95M54	—	0.952	Q95M54 →
P30873	—	0.950	P30873 →
SSTR5	Somatostatin receptor type 5	0.950	landscape →
P79350	—	0.950	P79350 →
Q9MYW9	—	0.948	Q9MYW9 →
P28646	—	0.947	P28646 →
CCKBR	Gastrin/cholecystokinin type B receptor	0.947	landscape →
P30552	—	0.944	P30552 →