Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.76 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.72 |
| ▸ | THPO | P40225 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521435 | 0.94 | HTR1A (0.75) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| Hydrochloric Acid SCHEMBL10517891 | 0.93 | HTR1A (0.76) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| SCHEMBL10658613 | 0.88 | HTR1A (0.70) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| Hydrochloric Acid SCHEMBL10519410 | 0.87 | HTR1A (0.69) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| SCHEMBL10519083 | 0.84 | HTR1A (0.65) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| Bmy-7378 SCHEMBL6017145 | 0.84 | HTR1A (1.00) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| Bmy-7378 SCHEMBL32690868 | 0.84 | HTR1A (1.00) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| SCHEMBL10519101 | 0.84 | HTR1A (0.58) | HTR1AADRA1B | |
| Bmy-7378 SCHEMBL987183 | 0.83 | HTR1A (1.00) | HTR1AADRA1BADRA1DADRA1AMEN1 | |
| Hydrochloric Acid SCHEMBL10519883 | 0.82 | HTR1A (0.56) | HTR1AADRA1BADRA1DADRA1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333137-A1 | Arylpiperazinylalkoxy derivatives of cyclic imides, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4826846-A | ANALGESIC, ANTIPSYCHOTIC | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-05-02 | — | — | US | disclosed |
| US-4780466-A | ANALGESICS, ANTIPSYCHOTIC AGENTS, ANXIOLYTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-10-25 | — | — | US | disclosed |