Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904153 | 0.87 | KDM4E (0.59) | SMN1; SMN2RXFP1KDM4EALDH1A1GAA | |
| SCHEMBL10517403 | 0.86 | KCNH2 (0.52) | GSTP1MAPTNPSR1MCL1SMN1; SMN2 | |
| SCHEMBL10516469 | 0.85 | KDM4E (0.54) | MAPTSMN1; SMN2RXFP1TP53KDM4E | |
| SCHEMBL10514341 | 0.82 | GSK3B (0.54) | MAPTSMN1; SMN2RXFP1KDM4EALDH1A1 | |
| SCHEMBL10483018 | 0.80 | KDM4E (0.51) | MAPTSMN1; SMN2RXFP1RAB9ATP53 | |
| SCHEMBL14867324 | 0.76 | SERPINE1 (0.55) | GSTP1MAPTMAPK1NPSR1NOD2 | |
| SCHEMBL14741167 | 0.75 | KDM4E (0.57) | MAPTSMN1; SMN2RXFP1KDM4EALDH1A1 | |
| SCHEMBL10515809 | 0.74 | MAOB (0.48) | MAPTNOD2MAOB | |
| SCHEMBL7991836 | 0.73 | DHODH (0.58) | MAPTSMN1; SMN2RAB9ATP53DHODH | |
| SCHEMBL6799282 | 0.73 | MCL1 (0.63) | GSTP1MCL1DHODHFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308020-A2 | 5-(aryl and heteroaryl)-6-(aryl and heteroaryl)-1,2-dihydro-2-oxo 3-pyridinecarboxylic acids and derivatives thereof | MERCK & CO. INC. (US) | 1989-03-22 | — | — | EP | claimed |