Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.63 |
| ▸ | F10 | P00742 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516140 | 0.86 | PDE3B (0.57) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL7423001 | 0.85 | PDE3B (0.56) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL10925412 | 0.85 | PDE3B (0.60) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL9182311 | 0.83 | PDE3B (0.54) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL8264680 | 0.81 | PDE3B (0.64) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL9180425 | 0.81 | PDE3B (0.52) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL9781454 | 0.81 | PDE3B (0.64) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL10769306 | 0.81 | PDE3B (0.60) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL10517959 | 0.81 | GPR119 (0.59) | PDE3BPDE3AF10GPR119ABCB11 | |
| SCHEMBL7295007 | 0.81 | PDE3B (0.51) | PDE3BPDE3AF10GPR119ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196005-B1 | PYRIDAZINONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |