Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10518681 | 0.92 | PDE3B (0.62) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10517966 | 0.92 | GPR119 (0.62) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10519090 | 0.91 | GPR119 (0.64) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10517769 | 0.88 | PDE3B (0.55) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10517959 | 0.83 | GPR119 (0.59) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10519085 | 0.82 | GPR119 (0.61) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10518157 | 0.82 | GPR119 (0.61) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10519857 | 0.80 | GPR119 (0.62) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10518321 | 0.80 | PDE3B (0.64) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10517762 | 0.80 | GPR119 (0.51) | PDE3BPDE3AABCB11MAOAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196005-B1 | PYRIDAZINONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |