Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.61 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.53 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520589 | 0.81 | GPR119 (0.56) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7280962 | 0.77 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7304363 | 0.75 | GPR119 (0.59) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10920730 | 0.74 | GPR119 (0.64) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9687991 | 0.74 | GPR119 (0.55) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10519891 | 0.74 | GPR119 (0.52) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL2584771 | 0.72 | GPR119 (0.64) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10520683 | 0.72 | GPR119 (0.53) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7306728 | 0.72 | PDE3B (0.60) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL2592011 | 0.70 | GPR119 (0.98) | PDE3BPDE3AGPR119PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196005-B1 | PYRIDAZINONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |