Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.85 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2583140 | 0.92 | GPR119 (1.00) | GPR119 | |
| SCHEMBL10522354 | 0.92 | GPR119 (0.83) | GPR119PDE3BPDE3A | |
| SCHEMBL10520468 | 0.90 | GPR119 (0.70) | GPR119PDE3BPDE3A | |
| SCHEMBL10519406 | 0.85 | GPR119 (0.64) | GPR119 | |
| SCHEMBL2590468 | 0.83 | GPR119 (0.98) | GPR119 | |
| SCHEMBL2590391 | 0.82 | GPR119 (1.00) | GPR119 | |
| SCHEMBL2590176 | 0.82 | GPR119 (0.83) | GPR119PDE3BPDE3A | |
| SCHEMBL2590196 | 0.82 | GPR119 (1.00) | GPR119PDE3BPDE3A | |
| SCHEMBL2584523 | 0.81 | GPR119 (1.00) | GPR119 | |
| SCHEMBL7331168 | 0.80 | GPR119 (0.62) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196005-B1 | PYRIDAZINONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |