Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 13/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766543 | 0.82 | DEGS1 (0.60) | SMN1; SMN2RAB9ANPC1MAPK1POLB | |
| SCHEMBL316074 | 0.80 | L3MBTL1 (0.52) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| SCHEMBL27749254 | 0.80 | — | — | |
| SCHEMBL28153323 | 0.78 | DEGS1 (0.58) | HSD17B10RAB9ANPC1POLB | |
| SCHEMBL5392914 | 0.77 | NR3C2 (0.41) | — | |
| SCHEMBL4573858 | 0.76 | HPGD (0.51) | ADORA3ADORA1ADORA2ASMN1; SMN2RAB9A | |
| SCHEMBL27909043 | 0.75 | GAA (0.54) | SMN1; SMN2RAB9ANPC1MAPK1 | |
| SCHEMBL4425197 | 0.75 | HSD17B10 (0.47) | HSD17B10ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL5346487 | 0.72 | KDM4E (0.41) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL4494048 | 0.72 | GSK3B (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106946890-A | Pyridines IRAK4 inhibitor, its preparation method and application | 中国药科大学 | 2017-07-14 | — | — | CN | disclosed |
| CN-1097417-A | New heterogeneous ring compound | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-01-18 | — | — | CN | disclosed |
| EP-0196005-B1 | PYRIDAZINONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |