SCHEMBL1051978

SCHEMBL1051978

NOC(=O)CC(N)c1ccccn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
MEN1 O00255 1/20 0.41
GAA P10253 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP1A2 P05177 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 3/20 0.39
KDM4E B2RXH2 3/20 0.39
TSHR P16473 3/20 0.39
SLC6A3 Q01959 2/20 0.39
LMNA P02545 2/20 0.39
ABCB11 O95342 1/20 0.39
ESR1 P03372 1/20 0.39
ADRA2A P08913 1/20 0.39
CYP2C9 P11712 1/20 0.39
PDE4A P27815 1/20 0.39
ADRA1A P35348 1/20 0.39
OPRK1 P41145 1/20 0.39
STAT6 P42226 1/20 0.39
HIF1A Q16665 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3283890 0.86 KCNA5 (0.52) SMN1; SMN2MEN1GAAKMT2ACYP1A2
SCHEMBL18176041 0.86 KCNA5 (0.52) SMN1; SMN2MEN1GAAKMT2ACYP1A2
Hydrochloric Acid SCHEMBL3283886 0.84 KCNA5 (0.51) SMN1; SMN2MEN1GAAKMT2ACYP1A2
Hydrochloric Acid SCHEMBL3283896 0.84 KCNA5 (0.51) SMN1; SMN2MEN1GAAKMT2ACYP1A2
SCHEMBL1051991 0.83 SMN1; SMN2 (0.55) SMN1; SMN2MEN1GAAKMT2ACYP1A2
SCHEMBL1077616 0.83 SMN1; SMN2 (0.55) SMN1; SMN2MEN1GAAKMT2ACYP1A2
Hydrochloric Acid SCHEMBL5742023 0.82 SMN1; SMN2 (0.53) SMN1; SMN2MEN1GAAKMT2ACYP1A2
Hydrochloric Acid SCHEMBL7321879 0.82 SMN1; SMN2 (0.53) SMN1; SMN2MEN1GAAKMT2ACYP1A2
SCHEMBL30915255 0.82 CYP2C19 (0.42) SMN1; SMN2MEN1GAAKMT2ACYP1A2
SCHEMBL19410196 0.82 CYP2C19 (0.42) SMN1; SMN2MEN1GAAKMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11371067-B2 Transaminase reactions CODEXIS, INC. (US) 2022-06-28 US disclosed
US-20200362377-A1 TRANSAMINASE REACTIONS INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2020-11-19 US disclosed
US-10767202-B2 Transaminase reactions CODEXIS, INC. (US) 2020-09-08 US disclosed
US-20190040431-A1 TRANSAMINASE REACTIONS INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2019-02-07 US disclosed
US-10138503-B2 Transaminase reactions CODEXIS, INC. (US) 2018-11-27 US disclosed
EP-2446026-B1 TRANSAMINASE REACTIONS CODEXIS INC (US) 2017-08-09 EP disclosed
US-20160333381-A1 TRANSAMINASE REACTIONS INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2016-11-17 US disclosed
US-9434968-B2 Transaminase reactions CODEXIS, INC. (US) 2016-09-06 US disclosed
US-20150079640-A1 TRANSAMINASE REACTIONS INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2015-03-19 US disclosed
US-8921079-B2 Transaminase reactions CODEXIS, INC. (US) 2014-12-30 US disclosed
US-20120190085-A1 Transaminase Reactions CODEXIS, INC. (US) 2012-07-26 US disclosed
EP-2446026-A1 TRANSAMINASE REACTIONS Codexis, Inc. (US) 2012-05-02 EP disclosed
WO-2011005477-A1 TRANSAMINASE REACTIONS CODEXIS, INC. (US) 2011-01-13 WO disclosed