Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520133 | 0.77 | KDM4E (0.48) | KMT2AMEN1MAPTGAACYP3A4 | |
| SCHEMBL10520127 | 0.77 | KDM4E (0.48) | KMT2AMEN1MAPTGAACYP3A4 | |
| SCHEMBL4432071 | 0.75 | KMT2A (0.65) | KMT2AMEN1MAPTCHRNB2CHRNA4 | |
| SCHEMBL404391 | 0.75 | MEN1 (0.69) | KMT2AMEN1MAPTCHRNB2CHRNA4 | |
| SCHEMBL28710258 | 0.75 | SMN1; SMN2 (0.56) | KMT2AMEN1MAPTCHRNB2CHRNA4 | |
| SCHEMBL1284855 | 0.74 | KMT2A (0.59) | KMT2AMEN1MAPTCHRNB2CHRNA4 | |
| SCHEMBL27548891 | 0.74 | KMT2A (0.59) | KMT2AMEN1MAPTCHRNB2CHRNA4 | |
| SCHEMBL13073769 | 0.74 | KMT2A (0.59) | KMT2AMEN1MAPTCHRNB2CHRNA4 | |
| SCHEMBL9555456 | 0.74 | CYP3A4 (0.53) | KMT2AMEN1CYP3A4CYP2C9MTNR1A | |
| SCHEMBL22323341 | 0.73 | MEN1 (0.66) | KMT2AMEN1MAPTCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |