Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520127 | 1.00 | KDM4E (0.48) | KDM4EGSK3BGAALMNAKMT2A | |
| SCHEMBL10523183 | 0.88 | MEN1 (0.48) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL10523190 | 0.88 | MEN1 (0.48) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7328215 | 0.83 | KDM4E (0.51) | KDM4EGAALMNAKMT2AMEN1 | |
| SCHEMBL7328223 | 0.83 | KDM4E (0.51) | KDM4EGAALMNAKMT2AMEN1 | |
| SCHEMBL5698294 | 0.78 | KDM4E (0.52) | KDM4EGAAKMT2AMEN1CYP3A4 | |
| SCHEMBL10477791 | 0.78 | KDM4E (0.50) | KDM4EGAALMNAKMT2AMEN1 | |
| SCHEMBL10477792 | 0.78 | KDM4E (0.50) | KDM4EGAALMNAKMT2AMEN1 | |
| SCHEMBL10519909 | 0.77 | KMT2A (0.52) | GAALMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL8865007 | 0.77 | KDM4E (0.55) | KDM4EGAAKMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |