Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520228 | 1.00 | ACE (0.49) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10522050 | 0.93 | ACE (0.46) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10522043 | 0.93 | ACE (0.46) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10385088 | 0.90 | ACE (0.51) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10385087 | 0.90 | ACE (0.51) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10385089 | 0.84 | ACE (0.49) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10385091 | 0.84 | ACE (0.49) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10384303 | 0.83 | ACE (0.49) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10384305 | 0.83 | ACE (0.49) | ACELMNASMN1; SMN2ALDH1A1ABCB11 | |
| SCHEMBL10383387 | 0.83 | ACE (0.48) | ACELMNASMN1; SMN2ABCB11FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886813-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1989-12-12 | — | — | US | disclosed |