Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521757 | 0.98 | TSHR (0.44) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL10522035 | 0.96 | TSHR (0.43) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL6813947 | 0.85 | TSHR (0.45) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL28556808 | 0.81 | TSHR (0.45) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL362721 | 0.79 | ALDH1A1 (0.52) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL10074949 | 0.79 | TSHR (0.44) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL142738 | 0.78 | SMN1; SMN2 (0.49) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL32677395 | 0.78 | SMN1; SMN2 (0.49) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL32677394 | 0.78 | SMN1; SMN2 (0.49) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B | |
| SCHEMBL31656250 | 0.78 | ALDH1A1 (0.50) | TSHRSMN1; SMN2ALDH1A1TDP1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808752-A | REACTING 2-AMINOBENZOTHIAZOLES WITH ALKALI HYDROXIDES; ALKYLATING AND HYDROLYZING THE RESULTING MERCAPTOPHENYLUREA SALT | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-28 | — | — | US | disclosed |