Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 7/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 6/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526781 | 0.91 | LATS1 (0.37) | IDO1KAT2BUTS2RSYKBRD4 | |
| SCHEMBL10524485 | 0.89 | TLR8 (0.45) | KAT2BUTS2RELANETLR8TLR7 | |
| SCHEMBL10524717 | 0.87 | KAT2B (0.38) | KAT2BBRD4CREBBP | |
| SCHEMBL10526790 | 0.87 | KAT2B (0.35) | IDO1KAT2BUTS2RSYK | |
| SCHEMBL10527375 | 0.86 | KAT2B (0.37) | KAT2BBRD4CREBBPCRBN | |
| SCHEMBL10526697 | 0.85 | IDO1 (0.37) | IDO1KAT2BBRD4CREBBP | |
| SCHEMBL10527283 | 0.83 | BRD4 (0.39) | KAT2BSYKBRD4CREBBP | |
| SCHEMBL10525166 | 0.81 | CCNB2 (0.37) | KAT2BSYKDDB1CRBN | |
| SCHEMBL10527810 | 0.81 | SYK (0.36) | SYKDDB1CRBNBTK | |
| SCHEMBL10527852 | 0.80 | KDM4E (0.34) | IDO1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801590-A | ANGINA, ANTICANCER, CARDIOVASCULAR DISORDERS, HEADACHES, PSORIASIS, ASTHMA, ANTICOAGULANTS | BEIERSDORF AG (DE) | 1989-01-31 | — | — | US | disclosed |
| EP-0253171-A1 | Pyrido[1,8]naphthyridinones, process for their preparation and their use and compositions containing them | Beiersdorf-Lilly GmbH (DE) | 1988-01-20 | — | — | EP | disclosed |