Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 14/20 | 0.50 |
| ▸ | ALPL | P05186 | 12/20 | 0.50 |
| ▸ | PLAA | Q9Y263 | 10/20 | 0.49 |
| ▸ | ALPI | P09923 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALPP | P05187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6010245 | 0.90 | ALPG (0.56) | ALPGALPLPLAAALPIGFER | |
| Bromide SCHEMBL10529429 | 0.84 | HSD17B3 (0.42) | ALPGALPITDP1L3MBTL1GAA | |
| Bromide SCHEMBL3849449 | 0.83 | KMT2A (0.44) | — | |
| Bromide SCHEMBL10528564 | 0.81 | KMT2A (0.49) | L3MBTL1GAA | |
| Bromide SCHEMBL3849697 | 0.81 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL29793862 | 0.80 | ALDH1A1 (0.51) | TDP1GAA | |
| SCHEMBL28841400 | 0.80 | ALDH1A1 (0.51) | TDP1GAA | |
| Bromide SCHEMBL3845993 | 0.79 | ALDH1A1 (0.47) | GAA | |
| Bromide SCHEMBL3850917 | 0.79 | NPC1 (0.46) | GAA | |
| SCHEMBL10531146 | 0.79 | KMT2A (0.50) | L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182533-B1 | 3-(2-ARYL-2-OXOETHYL)-IMIDAZOLIUM SALTS AS HYPOGLYCEMIC AGENTS | ELI LILLY AND COMPANY (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4683312-A | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1987-07-28 | — | — | US | disclosed |
| US-4609670-A | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1986-09-02 | — | — | US | disclosed |
| EP-0182533-A2 | 3-(2-Aryl-2-oxoethyl)-imidazolium salts as hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1986-05-28 | — | — | EP | disclosed |