Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 17/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10527187 | 0.89 | HRH1 (0.73) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10483537 | 0.85 | HRH1 (0.80) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10482964 | 0.85 | HRH1 (0.76) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10529770 | 0.84 | HRH1 (0.66) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10529778 | 0.84 | HRH1 (0.66) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10527191 | 0.83 | HRH1 (0.73) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10527210 | 0.82 | HRH1 (0.68) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10527217 | 0.82 | HRH1 (0.68) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL10338043 | 0.81 | HRH1 (0.71) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| Acetic Acid SCHEMBL10529808 | 0.81 | HRH1 (0.69) | HRH1CYP2D6KCNH2CHRM1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4857536-A | Antihistaminic benzimidazole derivatives | SYNTHELABO (FR) | 1989-08-15 | — | — | US | disclosed |