SCHEMBL10535166

SCHEMBL10535166

C=Cc1cccnc1.C=Cc1cncc(C)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.48
TP53 P04637 1/20 0.48
ALOX5 P09917 3/20 0.45
PTGS1 P23219 2/20 0.45
PTGS2 P35354 2/20 0.45
ALDH1A1 P00352 4/20 0.43
CYP11B2 P19099 2/20 0.43
CYP11B1 P15538 1/20 0.43
CYP19A1 P11511 3/20 0.41
NPC1 O15118 3/20 0.41
MAPT P10636 3/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
LMNA P02545 1/20 0.41
NAMPT P43490 1/20 0.40
CYP2A6 P11509 1/20 0.40
GRM5 P41594 1/20 0.39
MAPK1 P28482 2/20 0.39
KDM4E B2RXH2 1/20 0.39
JUN P05412 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL989929 0.85
SCHEMBL20995 0.83
SCHEMBL29522900 0.83
SCHEMBL27985473 0.81
Hydrochloric Acid SCHEMBL1389458 0.81
Bromide SCHEMBL1389398 0.81
Iodide SCHEMBL11295890 0.81
Bromide SCHEMBL27867752 0.81
Butadiene SCHEMBL4378692 0.79 ALDH1A1 (0.54) TDP1ALOX5PTGS1PTGS2ALDH1A1
SCHEMBL5961935 0.77 ALDH1A1 (0.52) ALOX5PTGS1PTGS2ALDH1A1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4857217-A ADDUCT OF POLYOLEFIN MODIFIED WITH AN ACID AND POLYAMINE MODIFIED WITH (THIO)AMIDO COMPOUND EXXON CHEMICAL PATENTS INC. (US) 1989-08-15 US disclosed