Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10537818 | 1.00 | MAPT (0.62) | MAPTRAB9ACYP1B1CYP1A1LMNA | |
| SCHEMBL2053680 | 0.79 | MAPT (0.55) | MAPTRAB9ACYP1B1CYP1A1LMNA | |
| SCHEMBL981600 | 0.77 | MAPT (1.00) | MAPTRAB9ACYP1B1CYP1A1LMNA | |
| SCHEMBL12948682 | 0.77 | MAPT (1.00) | MAPTRAB9ACYP1B1CYP1A1LMNA | |
| SCHEMBL29429080 | 0.75 | ALDH1A1 (0.76) | MAPTCYP1B1LMNAALDH1A1MAPK1 | |
| SCHEMBL14692643 | 0.75 | ALDH1A1 (0.76) | MAPTCYP1B1LMNAALDH1A1MAPK1 | |
| SCHEMBL21083529 | 0.75 | ALDH1A1 (0.68) | MAPTLMNAALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL14692644 | 0.75 | ALDH1A1 (0.76) | MAPTCYP1B1LMNAALDH1A1MAPK1 | |
| SCHEMBL19781128 | 0.75 | ALDH1A1 (0.68) | MAPTLMNAALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL10384632 | 0.74 | MAPT (0.65) | MAPTRAB9ACYP1B1CYP1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4800207-A | Hexahydropyrrolizine compounds useful as analgesics | MCNEILAB, INC. (US) | 1989-01-24 | — | — | US | disclosed |