SCHEMBL10545367

SCHEMBL10545367

COC(=O)c1ccccc1NC(=O)C(=Cc1ccc(OC)c(OC)c1)C(=O)Nc1ccccc1C(=O)OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.55
GAA P10253 5/20 0.55
HPGD P15428 5/20 0.55
KDM4E B2RXH2 4/20 0.55
KMT2A Q03164 4/20 0.55
SMN1; SMN2 Q16637 4/20 0.55
NPSR1 Q6W5P4 3/20 0.55
MEN1 O00255 3/20 0.55
LMNA P02545 3/20 0.55
TP53 P04637 2/20 0.55
CYP3A4 P08684 2/20 0.55
HIF1A Q16665 2/20 0.55
HSD17B10 Q99714 2/20 0.55
MAPK1 P28482 2/20 0.55
CYP1A2 P05177 2/20 0.55
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
NPC1 O15118 1/20 0.55
ABCC4 O15439 1/20 0.55
HPGDS O60760 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10502477 0.90 MEN1 (0.67) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL10504215 0.83 SMN1; SMN2 (0.57) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL9973827 0.81 ALDH1A1 (0.82) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL10497314 0.81 ALDH1A1 (0.82) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL21465861 0.80 DHODH (0.68) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL21465860 0.80 DHODH (0.68) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL297546 0.79 MEN1 (0.65) ALDH1A1HPGDKDM4EKMT2ASMN1; SMN2
SCHEMBL10730475 0.78 ALDH1A1 (0.70) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL10730474 0.78 ALDH1A1 (0.70) ALDH1A1GAAHPGDKDM4EKMT2A
SCHEMBL28942213 0.78 KMT2A (0.50) ALDH1A1GAAHPGDKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4822791-A ANTIALLERGENS SAWAI PHARMACEUTICAL CO., LTD. (JP) 1989-04-18 US disclosed
US-4755506-A Pharmaceutical compositions of [(1,3,-dioxo-1,3-propanediyl)diimino]bisbenzoic acid derivatives and their use SAWAI PHARMACEUTICAL CO., LTD. (JP) 1988-07-05 US disclosed
US-4634777-A HYALURONIDASE INHIBITORS SAWAI PHARMACEUTICAL CO., LTD. (JP) 1987-01-06 US disclosed
EP-0156456-A1 [(1,3,-dioxo-1,3-propanediyl)diimino] bisbenzoic acid derivatives and their use SAWAI PHARMACEUTICAL CO., LTD. (JP) 1985-10-02 EP disclosed