SCHEMBL105459

SCHEMBL105459

O=C(Cl)c1cccnc1Cl

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.70
LMNA P02545 2/20 0.70
EGFR P00533 4/20 0.53
POLB P06746 1/20 0.51
NPC1 O15118 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
GFER P55789 1/20 0.47
KDM4E B2RXH2 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
ALDH1A1 P00352 2/20 0.47
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29799007 1.00 SMN1; SMN2 (0.70) SMN1; SMN2LMNAEGFRPOLBNPC1
Fluoride SCHEMBL27809811 0.98 SMN1; SMN2 (0.68) SMN1; SMN2LMNAEGFRPOLBNPC1
Hydrochloric Acid SCHEMBL2683707 0.98 SMN1; SMN2 (0.68) SMN1; SMN2LMNAEGFRPOLBNPC1
Methylene Chloride SCHEMBL28852627 0.94 SMN1; SMN2 (0.63) SMN1; SMN2LMNAEGFRPOLBNPC1
Chlorobenzene SCHEMBL28789753 0.91 SMN1; SMN2 (0.65) SMN1; SMN2LMNAEGFRPOLBNPC1
SCHEMBL8108070 0.85 SMN1; SMN2 (0.53) SMN1; SMN2LMNAEGFRPOLBNPC1
SCHEMBL950218 0.84 LMNA (0.73) SMN1; SMN2LMNAEGFRPOLBNPC1
SCHEMBL29412848 0.83 SMN1; SMN2 (1.00) SMN1; SMN2LMNAEGFRPOLBNPC1
SCHEMBL30792459 0.83 SMN1; SMN2 (1.00) SMN1; SMN2LMNAEGFRPOLBNPC1
SCHEMBL17180592 0.83 LMNA (0.70) SMN1; SMN2LMNAEGFRPOLBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2043 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025074339-A1 A PROCESS FOR PREPARATION OF CARBOXAMIDE COMPOUNDS AND INTERMEDIATES THEREOF UPL LIMITED (IN) 2025-04-10 WO claimed
CN-119480910-A Lithium battery composite aluminum foil and preparation method thereof 浙江大学 2025-02-18 CN claimed
CN-119424426-A Application of X201415 acting on GPR75 protein in preparation of medicine for treating non-alcoholic steatohepatitis 中国药科大学 2025-02-14 CN claimed
CN-119431424-A Silicon oxime ester-containing photoinitiator, preparation method and application thereof 常州强力先端电子材料有限公司 2025-02-14 CN claimed
CN-119285539-A Continuous preparation method of herbicide intermediate 2-chloronicotinyl chloride 湖北泰盛化工有限公司 2025-01-10 CN claimed
CN-119080689-A Botrytis cinerea method for synthesizing amine 浙江新安化工集团股份有限公司 2024-12-06 CN claimed
CN-118772051-A 2-Methylamino-3-pyridine methanol composition and preparation method thereof 北京海美桐医药科技有限公司 2024-10-15 CN claimed
CN-117209504-B Method for synthesizing pranoprofen intermediate and method for synthesizing pranoprofen by intermediate 济南国鼎医药科技有限公司 2024-06-25 CN claimed
CN-112851547-B Fluorene oxime ester compound, preparation method thereof and photosensitive resin composition 常州强力先端电子材料有限公司 2024-06-07 CN claimed
CN-117986232-A Oxime ester photoinitiator, preparation method and application thereof 常州强力电子新材料股份有限公司 2024-05-07 CN claimed
US-7241896-B2 Method for producing 2-halogen-pyridine-carboxylic acid amides BASF AKTIENGESELLSCHAFT (DE) 2007-07-10 US claimed
WO-2007010352-A1 AN IMPROVED PROCESS FOR INDUSTRIAL MANUFACTURE OF NEVIRAPINE EMCURE PHARMACEUTICALS LIMITED (IN) 2007-01-25 WO claimed
EP-1444205-B1 METHOD FOR PRODUCING 2-HALOGEN-PYRIDINE-CARBOXYLIC ACID AMIDES BASF AG (DE) 2006-02-01 EP claimed
US-20040266837-A1 Method for producing 2-halogen-pyridine-carboxylic acid amides BASF AKTIENGESELLSCHAFT (DE) 2004-12-30 US claimed
EP-0708092-A1 Process for the preparation of 3-aminopyridines from 3-nitropyridines MERCK PATENT GmbH (DE) 1996-04-24 EP claimed
CN-1115755-A Method for preparing 3-aminopyridines from 3-nitropyridines MERCK PATENT GMBH (DE) 1996-01-31 CN claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 EP claimed
US-4144238-A Process for the production of pure white 2-chloronicotinic acid LONZA, LTD. (CH) 1979-03-13 US claimed
US-4081451-A Process for preparing 2-halogeno nicotinic acids SCHERING CORPORATION (US) 1978-03-28 US claimed
US-4080336-A Process for the production of 2-chloronicotinic acid amide LONZA LTD. (CH) 1978-03-21 US claimed