SCHEMBL105469

SCHEMBL105469

N#Cc1ccccc1/N=N/c1ccc(O)c2ncccc12

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 11/20 0.65
KMT2A Q03164 11/20 0.65
MAPT P10636 8/20 0.65
TDP1 Q9NUW8 6/20 0.65
L3MBTL1 Q9Y468 5/20 0.65
SMN1; SMN2 Q16637 5/20 0.65
HTT P42858 5/20 0.65
MAPK1 P28482 5/20 0.65
LMNA P02545 3/20 0.65
OPRK1 P41145 2/20 0.65
GLO1 Q04760 5/20 0.64
HSP90AA1 P07900 4/20 0.61
NPC1 O15118 4/20 0.61
NSD2 O96028 2/20 0.61
KLF5 Q13887 2/20 0.61
CASP6 P55212 2/20 0.61
TNF P01375 1/20 0.61
CXCL8 P10145 1/20 0.61
PAX8 Q06710 1/20 0.61
POLB P06746 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8531824 0.83 MEN1 (0.76) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL27893542 0.80 GLO1 (0.71) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL4465315 0.79 GLO1 (1.00) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL4465316 0.79 GLO1 (1.00) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL5851384 0.78 GLO1 (0.88) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL5851373 0.78 GLO1 (0.88) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL1187421 0.78 HSP90AA1 (0.61) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL4301084 0.76 HSP90AA1 (0.59) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL8180055 0.76 GLO1 (0.68) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL8180059 0.76 GLO1 (0.68) MEN1KMT2AMAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2188394-B1 IDENTIFICATION OF NUCLEIC ACID SEQUENCES UNIV STRATHCLYDE (GB) 2015-06-24 EP disclosed
US-20120058471-A1 IDENTIFICATION OF NUCLEIC ACID SEQUENCES UNIVERSITY OF STRATHCLYDE (GB) 2012-03-08 US disclosed
US-20120058471-A1 IDENTIFICATION OF NUCLEIC ACID SEQUENCES UNIVERSITY OF STRATHCLYDE (GB) 2012-03-08 US disclosed
WO-2009022125-A1 IDENTIFICATION OF NUCLEIC ACID SEQUENCES UNIVERSITY OF STRATHCLYDE (GB) 2009-02-19 WO disclosed