Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293060 | 0.82 | PDE3B (0.54) | KCNJ1PDE3BPDE3ACYP11B2PDE2A | |
| SCHEMBL11006142 | 0.71 | PDE3B (0.52) | PDE3BPDE3ACYP11B2PDE2APDE1A | |
| SCHEMBL30899605 | 0.70 | KCNJ1 (0.49) | KCNJ1PDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL1735017 | 0.68 | TRIM24 (0.53) | KCNJ1TRIM24TRIM33ALDH1A1KDM4E | |
| SCHEMBL20797345 | 0.68 | KCNJ1 (0.46) | KCNJ1ALDH1A1KDM4E | |
| SCHEMBL20797535 | 0.68 | KCNJ1 (0.46) | KCNJ1ALDH1A1KDM4E | |
| SCHEMBL20810916 | 0.68 | KCNJ1 (0.46) | KCNJ1ALDH1A1KDM4E | |
| SCHEMBL20797611 | 0.68 | KCNJ1 (0.46) | KCNJ1ALDH1A1KDM4E | |
| SCHEMBL10549917 | 0.68 | FGFR1 (0.57) | KCNJ1 | |
| SCHEMBL24409182 | 0.68 | KCNJ1 (0.47) | KCNJ1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |